Inflammatory Proteins Tied to Depression in Diabetes
People with both type-1 and type-2 diabetes have an increased risk of developing depression, but the reasons for this remain poorly understood.
Now a new study published in the journal Endocrine Connections finds that depression in type-1 diabetes patients is linked to higher levels of an inflammatory protein known as galectin-3. The findings suggest that measuring levels of galectin-3 could be useful for diagnosis of depression or perhaps as a new target for treating depression associated with type-1 diabetes.
Galectin-3 is a key protein involved in producing the inflammatory immune system responses that are necessary to repair tissue damage throughout the body in response to injury or disease. However, increased levels of galectin-3 have also been associated with a greater risk of inflammatory disorders such as Alzheimer’s disease or cardiovascular disease.
And although prior research has shown that both depression and diabetes may be linked to increased levels of inflammation in the body, the role of galectin-3 has not been investigated in either condition until now.